Antihypertensive 2H-indol-2-ones

Details Antihypertensive 2H-indol-2-ones Antihypertensive 2H-indol-2-ones

1979-03-15

1980-09-23

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

546197, 546201, 546216, 2603403, A61K 31445, C07D40514

Patent

active

042243335

ABSTRACT:
Novel optically active isomers or racemates of 1,3-dihydro-3-{1-[2-(2,3-dihydro-1,4-benzodioxin-2-yl)-2-hydroxyethyl]-pip eridin-4-yl}-2H-indol-2-ones of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen, chlorine, bromine, fluorine and alkoxy of 1 to 5 carbon atoms and R.sub.2 is selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having antihypertensive activity and a novel process and intermediates for their preparation.

REFERENCES:
patent: 3644403 (1972-02-01), Canas-Rodriguez et al.
patent: 3720670 (1973-03-01), Nakanishi et al.
patent: 3850938 (1974-11-01), Derible et al.
patent: 3947578 (1976-03-01), Derible et al.
patent: 4100291 (1978-07-01), Clemence et al.

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