Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1985-04-26
1987-06-09
Ford, John M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514343, 514356, 546281, 546283, 546284, 546321, C07D21190, C07D40112, C07D40512, A61K 31455
Patent
active
046720685
ABSTRACT:
1,4-dihydropyridine derivatives represented by the following general formula, ##STR1## in which R.sup.3 is a combination of an unsaturated straight chain hydrocarbon group or derivative thereof connected by a single bond with an unsaturated hydrocarbon group or derivative thereof so that the unsaturated carbon atoms of the two groups are in conjugated relationship. These compounds have a hypotensive action the effective time of which is long, which makes the blood pressure descend slowly, and the toxicity of which is low.
REFERENCES:
patent: 4044141 (1977-08-01), Bossert et al.
patent: 4370334 (1983-01-01), Sato
patent: 4532248 (1985-07-01), Franckowiak et al.
Derwent Abstract of Belgian No. 893,984, 1/31/83.
Bossert, F. et al, "4-Aryldihydropyridines" Angew. Chem. Int. Ed. Engl., 20 (1981) pp. 762-769.
Schramm, M. et al, "Novel Dihydropyridines with Positive Inotropic Action" Nature, vol. 303 (9 Jun. '83), pp. 535-537.
Ikawa Hiroshi
Kutsuma Teruo
Sato Yoshiaki
Bjorkman Dale A.
Ford John M.
Fujirebio Kabushiki Kaisha
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