Antihyperlipidemic amine boranes

Details Antihyperlipidemic amine boranes Antihyperlipidemic amine boranes

1987-02-05

1988-04-26

Meyers, Albert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Boron containing doai

A61K 3169

Patent

active

047405040

ABSTRACT:
Trialkylamine borane compounds are useful as antihyperlipidemic agents for lowering serum cholesterol and triglyceride levels in mammals.

REFERENCES:
patent: 3011922 (1961-12-01), Anderson
patent: 3227762 (1966-01-01), Brown et al.
patent: 4312989 (1982-01-01), Spielvogel
patent: 4368194 (1983-01-01), Spielvogel et al.
Hall, I. H.: Hypolipidemic Activity of N,N-Dimethyl-n-Octadecyl amine Borane in Rodents, J. Pharm. Sci., 75: (7), 706-710, (1986).
Hall, I. H.: "Hypolipidemic Activity of Boron Analogs in Rodents", Abstr., 36 Southeastern Reg. Meeting, American Chemical Society, Oct. 24-26, 1984, Abst. #332.
Hall, I. H.; Williams, W. L., Gilbert, C. J., McPhail, T. and Spielvogel, B. F., Hypolipidemic Activity of Tetrakis-.mu.-(Trimethylamine-Borane Carboxylato)-bis(Trimethylamine-Carboxyborane)-Copper(II) in Rodents and Its Effect on Lipid Metabolism, J. Pharm. Sci., 73(7), 973-977, 1984.
Hall, I. H., Das, M. K., Harchelroad, F., Jr., Wisian-Neilson, P., McPhail, A. T., and Spielvogel, B. F., Antihyperlipidemic Activity of Amine Cyanoboranes, Amine Carboxyboranes, and Related Compounds, J. Pharm. Sci., 70(3), 339-340, 1981.

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