Antihypercholesterolemic tri-yne carbonates

Details Antihypercholesterolemic tri-yne carbonates Antihypercholesterolemic tri-yne carbonates

1987-05-26

1988-10-25

Meyers, Albert T.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

514467, A61K 3174, A61K 31335

Patent

active

047803118

ABSTRACT:
The compounds of the following general structural formula (I) ##STR1## wherein R is hydrogen or a pharmaceutically acceptable salt thereof, are .beta.-ketoacyl-coenzyme A thiolase inhibitors and are useful as antihypercholesterolemic agents for the treatment of disease in which the inhibition of cholesterol biosynthesis would be useful, such as arteriosclerosis, hyperlipidemia and familial hypercholesterolemia.

REFERENCES:
M. Mehrabian et al., "Regulation of Rat Liver 3-Hydroxy-3-Methylglutaryl Coenzyme A Synthetase and the Chromasomel Localization of the Human Gene," J. Biol. Chem., 261:16249-16255 (1986).
K. Higuchi, "An Improved Chemically Refined Culture Medium for Strain L Mouse Cells Based on Growth Responses to Graded Levels of Nutrients Including Iron and Zinc Ions," J. Cell. Physiol., TS:65-72 (1972).
S. Zamenhof, "Preparation and Assay of Deoxyribonucleic Acid from Animal Tissue," Methods Enzymol., 3:696-704 (1957).

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