Antihypercholesterolemic compounds and synthesis thereof

Details Antihypercholesterolemic compounds and synthesis thereof Antihypercholesterolemic compounds and synthesis thereof

1990-04-17

1993-05-04

Prescott, Arthur C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

514 63, 514512, 514533, 514784, 514785, 514824, 560248, 560256, 435135, 435136, 562531, 562533, C07D30930, C07C 6928, A61K 3122

Patent

active

052082580

ABSTRACT:
A method of preparing compactin and mevinolin, ketoacid, enone, and glutarate analogs thereof, and related compounds. The compounds are prepared in substantially enantiomerically pure form using a structurally convergent synthesis. Total syntheses of (+)-compactin, (+)-mevinolin and related compounds are provided. Novel compounds are identified, several of which show significant anti-hypercholesterolemic activity.

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