Antihypercholesterolemic compounds and synthesis thereof

Details Antihypercholesterolemic compounds and synthesis thereof Antihypercholesterolemic compounds and synthesis thereof

1985-10-11

1990-08-21

Shaver, Paul F.

Gas separation

549292, 549417, 560 86, 560 89, C07F 708, C07F 718

Patent

active

049507753

ABSTRACT:
A method of preparing compactin and mevinolin, ketoacid, enone, and glutarate analogs thereof, and related compounds. The compounds are prepared in substantially enantiomerically pure form using a structurally convergent synthesis. Total syntheses of (+)-compactin, (+)-mevinolin and related compounds are provided. Novel compounds are identified, several of which show significant anti-hypercholesterolemic activity.

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