Antihypercholesterolemic compounds and related pharmaceutical co

Details Antihypercholesterolemic compounds and related pharmaceutical co Antihypercholesterolemic compounds and related pharmaceutical co

1992-06-12

1996-04-23

Rizzo, Nicholas

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514176, 540 49, 540 50, 540 59, 540 61, C07J 7100, A61K 3158

Patent

active

055103405

ABSTRACT:
Novel antihypercholesterolemic agents are provided. An exemplary group of compounds has the structural formula (I) ##STR1## wherein R is a C-17 side chain, R.sup.1 is --OH, .dbd.O, or the like, and X and Y are N, N.fwdarw.O, CH, C--OH, C--OCH.sub.3 or C--Z. Methods of using the compound of formula (I) or other novel oxysterol analogs to treat hypercholesterolemia are provided, as are pharmaceutical compositions containing the compounds.

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