Antihypercholesterolemic compounds

Details Antihypercholesterolemic compounds Antihypercholesterolemic compounds

1988-07-18

1989-08-08

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514824, 514460, 514534, 514570, 562469, 560 59, 549292, C07C 6976

Patent

active

048553212

ABSTRACT:
Novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors which are useful as antihypercholesterolemic agents and are represented by the following general structural formulae (I) and (II): ##STR1## and pharmaceutically acceptable salts of the compounds (II) in which Z is hydrogen are disclosed.

REFERENCES:
patent: 4459422 (1984-07-01), Willard et al.
patent: 4567289 (1986-01-01), Willard et al.
patent: 4772626 (1988-09-01), Smith et al.
Willard et al. III "(+)-(4R,6S)-(E)-6-[2-(4'-fluoro-3,3',5-trimethyl-[1,1'-biphenyl]-2-yl)eth enyl]-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-one and a pharmaceutical composition containing it", CA 98 179222x (1983).

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