Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1987-05-26
1989-02-21
Hollrah, Glennon H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
549263, 549328, A61K 31365, C07D30508
Patent
active
048065641
ABSTRACT:
The compounds of the following structural formula (I) ##STR1## are 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) synthase inhibitors and useful as antihypercholesterolemic agents for the treatmet of disease in which the inhibition of cholesterol biosynthesis would be useful, such as arteriosclerosis, hyperlipidemia and familial hypercholesterolemia.
REFERENCES:
patent: 4358602 (1982-11-01), Umezawa et al.
patent: 4598089 (1986-07-01), Haduary et al.
patent: 4751237 (1988-06-01), Chabala et al.
Chemical Communications, 1970, p. 639 [(Chem. Abstracts; vol. 73 #55594j (1970)].
J. Chem. Soc. (c), 1971, pp. 3888-3890 [(Chem. Abstracts; vol. 76, #45686)].
Chabala John C.
Chang Michael N.
Chiang Yuan-Ching P.
Graham Donald W.
Heck James V.
DiPrima Joseph F.
Hollrah Glennon H.
Merck & Co. , Inc.
Sudol Michael C.
Treanor S.
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