Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1986-04-28
1988-06-14
Robinson, Allen J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
424 78, A61K 31335, A61K 3174
Patent
active
047512377
ABSTRACT:
The compounds of the following general structural formula (I) ##STR1## wherein R is hydrogen or C.sub.1-3 alkyl and the tetrahydro analogs thereof, are 3-hydroxy-3-methylglutarylcoenzyme A (HMG-CoA) synthase inhibitors and useful as antihypercholesterolemic agents for the treatment of disease in which the inhibition of cholesterol biosynthesis would by useful, such as arteriosclerosis, hyperlipidemia and familial hypercholesterolemia.
REFERENCES:
patent: 2970053 (1961-01-01), Martin et al.
patent: 3074795 (1963-01-01), Friedman et al.
patent: 3538216 (1970-11-01), Polin
Chemical Communications, 1970, p. 639 [(Chem. Abstracts; vol. 73 #55594j (1970)].
J. Chem. Soc. (c), 1971, pp. 3888-3890 [(Chem. Abstracts; vol. 76, #45686p (1972)].
Chabala John C.
Greenspan Michael D.
Patchett Arthur A.
DiPrima Joseph F.
Kearse Richard
Merck & Co. , Inc.
Robinson Allen J.
Sudol Michael C.
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