Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1987-03-04
1989-07-11
Lee, Mary C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514449, 546268, 549328, A61K 31365, A61K 3144, C07D30512, C07D40512
Patent
active
048472719
ABSTRACT:
The compounds of the following general structural formula (I) ##STR1## are 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) synthase inhibitors and useful as antihypercholesterolemic agents for the treatment of disease in which the inhibition of cholesterol biosynthesis would be useful, such as arteriosclerosis, hyperlipidemia and familial hypercholesterolemia.
REFERENCES:
Chemical Communications, 1970, p. 639 [(Chem. Abstracts; vol. 73, #55594j (1970)].
J. Chem. Soc. (c), 1971, pp. 3888-3891 [(Chem. Abstracts; vol. 76, #45686P (1972)].
Chabala John C.
Chang Michael N.
Chiang Yuan-Ching P.
Girotra Narindar M.
Graham Donald W.
DiPrima Joseph F.
Howard Mary Sue
Lee Mary C.
Merck & Co. , Inc.
Winokur Melvin
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