Antihistaminic piperidinyl benzimidazoles

Details Antihistaminic piperidinyl benzimidazoles Antihistaminic piperidinyl benzimidazoles

1988-10-13

1990-03-13

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546199, A61K 31445, C07D40106

Patent

active

049083724

ABSTRACT:
The present invention is directed to a new class of piperidinyl benzimidazole antihistamines which can be described by the following formula: ##STR1## wherein Y is represented by CO or CHOH; m is an integer from 1 to 2; R is represented by C.sub.1-4 alkyl, C.sub.1-4 alkoxy, halogen, hydroxy and hydrogen, X is represented by hydrogen, COOR.sub.2 in which R.sub.2 is represented by a C.sub.1-4 alkyl, or X is an alkylene phenyl radical of the formula: ##STR2## wherein T is represented by CHOH, CO, O, or a direct bond; R.sub.1 is represented by C.sub.1-4 alkyl, C.sub.1-4 alkoxy, halogen, hydroxy, 2,2-dimethyl ethanoic acid and hydrogen; n is an integer from 1 to 5; or a pharmaceutically acceptable acid addition salt thereof.

REFERENCES:
patent: 3878217 (1975-04-01), Carr et al.
patent: 4219559 (1980-08-01), Janssens et al.
patent: 4254129 (1981-03-01), Carr et al.
patent: 4285957 (1981-08-01), Carr et al.
patent: 4695575 (1987-09-01), Janssens et al.
S. Ohta et al., Chem. Pharm. Bull. 34(12), 4916-4926 (1986).

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