Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Patent
1980-10-03
1982-04-13
Schwartz, Richard A.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
4242484, 42424854, 42424857, 42424858, 424272, 424273R, 542470, 544 63, 544 96, 544139, 546210, 548215, 548336, 548342, 548343, 564246, 564276, A61K 31445, C07D23364
Patent
active
043247920
ABSTRACT:
The present invention provides compounds of the general formula (I) ##STR1## and physiologically acceptable salts and bioprecursors thereof in which ##STR2## represents either ##STR3## R.sup.1 represents hydrogen, halogen, C.sub.1-4 alkoxy, hydroxy, alkyl, R.sup.4 CH(OH)--, cyano or R.sup.5 CONH--, R.sup.2 and R.sup.3, which may be the same or different, each represents a straight or branched chain alkyl group or alkenyl group or R.sup.2 and R.sup.3 may, together with the nitrogen atom to which they are attached, form a saturated heterocyclic ring containing from 5 to 7 members which may optionally contain an oxygen atom; R.sup.4 represents hydrogen or alkyl; and R.sup.5 represents hydrogen, alkyl or C.sub.1-4 alkoxy. The compounds have been shown to exhibit H.sub.1 -antagonist activity in standard pharmacological tests.
REFERENCES:
patent: 2532547 (1950-12-01), Goldberg et al.
patent: 3953460 (1976-04-01), Durant et al.
patent: 4152443 (1979-05-01), Durant et al.
Labelle, A., et al., J. Pharm. Exp. Ther., 113, 72-88, (1955).
Merck Index, Ninth Edition, p. 279.
Bradshaw John
Oxford Alexander W.
Scopes David I. C.
Glaxo Group Limited
Schwartz Richard A.
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