Antihistaminic and bronchospasmolytic triazoloquinazolinones

Details Antihistaminic and bronchospasmolytic triazoloquinazolinones Antihistaminic and bronchospasmolytic triazoloquinazolinones

1981-02-13

1982-09-21

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

42424857, 544251, 544115, 544287, A61K 31505, C07D48704

Patent

active

043506950

ABSTRACT:
Novel triazoloquinazolinones of the formula ##STR1## wherein X is selected from the group consisting of hydrogen, halogen, --NO.sub.2, methyl, methoxy and --CF.sub.3, n is an integer from 2 to 5, R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and alkyl and hydroxyalkyl of 1 to 5 carbon atoms and taken together with the nitrogen atom to which they are attached form a saturated heterocycle optionally containing another heteroatom and optionally substituted with at least one member of the group consisting of hydroxy, alkyl and hydroxyalkyl of 1 to 5 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, acyl of an aliphatic carboxylic acid of 1 to 5 carbon atoms, alkoxycarbonyl of 2 to 6 carbon atoms and aryl optionally substituted with a halogen or --CF.sub.3 and their non-toxic, pharmaceutically acceptable acid addition salts having antihistaminic and bronchospasmolytic activity and their preparation.

REFERENCES:
patent: 3850932 (1974-11-01), Kathawala
Bowie, et al., Chemical Abstracts, vol. 92, 128148w (1980), J. Chem. Soc., Perkin Trans., 2/79 (12), pp. 1708-1714.

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