Antihistamine formulations for soft capsule dosage forms

Details Antihistamine formulations for soft capsule dosage forms Antihistamine formulations for soft capsule dosage forms

2007-04-10

2007-04-10

Kennedy, Sharon E. (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

C424S452000, C424S456000, C424S462000

Reexamination Certificate

active

10384868

ABSTRACT:
The invention herein relates to a pharmaceutical composition containing loratadine and derivatives thereof which is suitable for use in soft capsule dosage forms. A pharmaceutical composition according to the invention comprises loratadine and derivatives thereof in a pharmaceutically effective amount; and a solvent system comprising a mixture of medium chain fatty acids. The loratadine compositions exhibit good solubility and storage stability while maintaining bioavailability of the drug. The compositions also permit high concentrations of solubilized loratadine per total fill volume and thereby permit the use of smaller capsules to deliver the same dosage of drug.

REFERENCES:
patent: 6248363 (2001-06-01), Patel et al.
patent: 2001/0036472 (2001-11-01), Wong et al.
patent: 2002/0012675 (2002-01-01), Jain et al.
patent: 2003/0104048 (2003-06-01), Patel et al.
patent: 2003/0108607 (2003-06-01), Szymczak

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