Antihemostatic Factor VII peptides

Details Antihemostatic Factor VII peptides Antihemostatic Factor VII peptides

1989-11-13

1993-03-02

Cashion, Jr., Merrell C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 514 13, 514 14, 530328, 530327, 530326, 530325, 530324, A61K 3700, A61K 3702, C07K 500, C07K 700

Patent

active

051909197

ABSTRACT:
A number of novel antihemostatic peptides are claimed. Included among the antihemostatic peptides claimed are R-T-K-L-F-W-I-S-Y-S-D-G-D-Q, Y-S-D-G-D-Q-C, L-L-V-N-G-A-Q-L-C, C-F-D-K-I-K-N-W-R-N-L-I-A-V-L-G-E-H-D-L-S, F-D-K-I-K-N-W-R-N-L-I-A-V-L-G-E-H-D-L-S-E-H-D-G-D-E-Q-S-R-R-V-A-Q-V-I, L-G-E-H-D-L-S-E-H-D-G-D-E-Q-S-R-R-V-A-Q-V-I, A-V-L-G-E-H-D-L-S-E-H-D-G, V-R-F-S-L-V-S-G-W-G-Q, G-Q-L-L-D-R-G-A-T-A-L-E-L-M-V-L-N-V-P-R-L, A-G-Y-S-D-G-S-K-D-S-C, P-H-A-T-H-Y-R-G-T-W-Y-L-T-G-I and V-Y-T-R-V-S-Q-Y-I-E-W-L-Q-K-L and their analogues. The peptides are useful for inhibiting the formation of the Factor VII-tissue factor macromolecular complex of for inhibiting the activation of Factor X by Factor VII.

REFERENCES:
patent: 4736018 (1988-04-01), Reutelingsperger
patent: 4772686 (1988-09-01), Szelke et al.
patent: 4791100 (1988-12-01), Kramer et al.
Hagen et al., Proc. Natl. Acad. Sci. USA, vol. 83, pp. 2412-2416 (1986).
Ohara et al., Proc. Natl. Acad Sci. USA, vol. 84, pp. 5158-5162 (1987).
Thim et al., Biochemistry, 27, pp. 7785-7793, 1988.

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