Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1991-11-12
1994-01-11
Russel, Jeffrey E.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530416, C07K 302, C07K 322, C07K 1506
Patent
active
052782891
ABSTRACT:
A method of recovering a purified and stabilized protein having antihemophilic factor activity (Factor VIII), from a biological sample containing Factor VIII, at least one destabilizing protease impurity, i.e. thrombin, and optionally one or more proprotease impurity, is provided. The biological sample is contacted with a protease removing and/or inhibiting agent, thereby inhibiting and/or removing the destabilizing protease impurity. The method provides increased yield and resolution of Factor VIII. Also provided are purified and stabilized Factor VIII non-lyophilized, liquid in compositions.
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Fulton Anne J.
Johnson Alan J.
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