Antihemophilic factor concentrate and method for preparation

Details Antihemophilic factor concentrate and method for preparation Antihemophilic factor concentrate and method for preparation

1980-02-26

1983-05-31

Rosen, Sam

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

A61K 3514

Patent

active

043860680

ABSTRACT:
Novel antihemophilic factor concentrates and process for making the same are disclosed. An aqueous solution of antihemophilic factor proteins is obtained, preferably by solubilizing antihemophilic factor proteins from blood plasma cryoprecipitate in water. The aqueous solution is purified to remove unwanted protein, for example, by mixing the aqueous solution with aluminum hydroxide. Then, the aqueous solution is ultrafiltered to concentrate it, mixed with buffer and saline and adjusted to an acid pH, and freeze-dried.

REFERENCES:
patent: 4170639 (1979-10-01), Liu
Liu et al.--Vox Sang, vol. 38 (1980) pp. 216-221.

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