Antihemophilic factor concentrate and its production

Details Antihemophilic factor concentrate and its production Antihemophilic factor concentrate and its production

1978-07-10

1979-10-09

Rosen, Sam

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

A61K 3516

Patent

active

041706390

ABSTRACT:
Antihemophilic factor (AHF) concentrate having enhanced potency and solubility and its process of production are provided. The process includes the steps of removing unwanted protein from an aqueous extract of antihemophilic blood plasma cryoprecipitate by mixing the aqueous extract with aluminum hydroxide at an acid pH in the cold, adjusting the purified aqueous extract to an acid pH and freeze-drying the extract, optionally removing water from the extract just before freeze-drying.

REFERENCES:
patent: 3652530 (1972-03-01), Johnson
patent: 3973002 (1976-08-01), Hagan
patent: 4087415 (1978-05-01), Bick et al.
patent: 4093608 (1978-06-01), Iga et al.
Swart et al.--Chem. Abst., vol. 77 (1972) p. 124,372g.

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