Antihelminthic anthraquinones and method of use thereof

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S510000, C514S548000, C552S208000, C552S261000, C552S262000, C552S265000, C552S266000, C552S267000

Reexamination Certificate

active

06903076

ABSTRACT:
Anthraquinones are described which are antihelminthic and in particular, are useful in compositions for inhibitingSchistosomasp. in vitro or in vivo. The preferred anthraquinones have the formula:wherein R1, R2, R3, and R4are each hydrogen, hydroxy, halogen, alkyl, substituted alkyl, alkene, substituted alkene, alkyne, aryl, substituted aryl, cyclic, substituted cyclic, acid group, carbohydrate, or combination thereof, R is a group containing 1 to 12 carbons such as methyl, alkyl, substituted alkyl, aldehyde, hydroxy, hydroxymethyl, acid group, carbohydrate, or combination thereof, and the halogen is I, F, Br, or Cl.

REFERENCES:
patent: 4117156 (1978-09-01), Loewe et al.
patent: 5091385 (1992-02-01), Gulliya et al.
patent: 5177073 (1993-01-01), Gulliya et al.
patent: 5489590 (1996-02-01), Gulliya et al.
Spainhour et al. (“Medical Attributes of Polygonum cuspidatum—Japanese knotweed”, Wilkes University, Jul. 1997, from the website: http://wilkes1.wilkes.edu/˜kklemow/Polygonum.html.
Chitsula et al., Acta Trop. 77: 41-51 (2000).
Bica et al., Infect. Dis. Clin. N. Am. 14: 637-642 (2000).
Elliot, Gastroenterol. Clin. N. Am. 25: 599-624 (1996).
Morris and Knauer, Sem. Respir. Infect. 12: 159-170 (1997).
Schafer and Hale, Curr. Gastroenterol. Reports 3: 293-303 (2001).
Cioli, Parasitol. Today 14: 418-422 (1998).
Curr. Opin. Infect Dis. 13: 659-663 (2000).
William et al., Parasitol. 122: 63-66 (2001).
Shiao et al., Acta Pharma. Sinica 9: 218-224 (1962).
Wang et al., Phytochem. 28: 1825-1826 (1989).
Wang and Yang, 1993, Acta Bot, Boreal., vol. 13(4).
Main et al., Aust. Vet. J. 57: 132-135 (1981).
Colegate et al., Aust. J. Chem. 38: 1233-1241 (1985).
Chen et al., Acta. Pharma. Sinica 9: 579-586 (1962).
Khan et al., In Synthesis 255-257 (1994).
Cameron et al., In Tetrahedron Letters 27: 4999-5002 (1986).
Baker and Myers, Pharmacol. Res. 8: 763-770 (1991).
Danielsen and Aksnes, Magn. Reson. Chem. 30: 359-360 (1992).
Schripsema et al., Phytochem. 51: 55-60 (1999).
Li and McLaughlin, J. Nat. Prod. 52: 660-662 (1989).
Midiwo and Arot., Int. J. BioChemiPhysics 2: 115-116 (1993).
Brauers et al., J. Nat. Prod. 63: 739-745 (2000).
Li et al., J. Nat. Prod. 63: 653-656 (2000).
Batterham et al., Aust. J. Chem. 14: 637-642 (1961).
Milovanovic et al., J. Serb. Chem. Soc. 61: 423-429 (1996).
Salter et al., J. Biol. Chem. 275: 38667-38673 (2000).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Antihelminthic anthraquinones and method of use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antihelminthic anthraquinones and method of use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antihelminthic anthraquinones and method of use thereof will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3479296

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.