Antiglobulin control cells

Details Antiglobulin control cells Antiglobulin control cells

1978-03-28

1982-04-20

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 68, 435240, 424 11, 424 12, 23230B, C12P 2100, C12N 500, G01N 3100

Patent

active

043260276

ABSTRACT:
Antiglobulin control cells are disclosed wherein reagent human red blood cells are coated with univalent antibody fragments. These control cells provide a high degree of specifity in determining the presence of active anti-human sera, which specifity is lacking in conventional Coombs control cells. The evaluation results of the reactivity tests may be performed in the present manner, but the positive hemagglutination provides assurance of anti-human sera activity as opposed to other agglutinating activity, such as protein that might be present.

REFERENCES:
patent: 3553310 (1971-01-01), Csizmas et al.
patent: 3914400 (1975-10-01), Shulman et al.
patent: 4107287 (1978-08-01), Morton et al.
patent: 4130634 (1978-12-01), Molinaro et al.
patent: 4166106 (1979-08-01), Sedlacek et al.
Stratton, et al, "Preparation of Test Cells for the Antiglobulin Test", Chem. Absts., vol. 81, No. 17, pp. 326-327 (1974), abs. No. 102906g.
Ssebabi, "Enzyme Antihuman-globulin Test, Technique to Detect Enzyme Autoantibody", Chem. Absts., vol. 80, No. 23, p. 322, (1974), abs. No. 131445y.

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