Chemistry: analytical and immunological testing – For preexisting immune complex or auto-immune disease – Rheumatoid factors
Patent
1994-06-03
1999-03-30
Housel, James C.
Chemistry: analytical and immunological testing
For preexisting immune complex or auto-immune disease
Rheumatoid factors
436506, 436516, 530350, 530403, C07K 100, C07K 1400, G01N 33564, G01N 33561
Patent
active
058888330
ABSTRACT:
The present invention relates to antigens extracted from mammalian malpighian epithelia, in particular rat esophageal epithelium or human epidermis, which are specifically recognized by the autoantibodies present in patients suffering form rheumatoid arthritis in respect of antigenic determinants in common with filaggrin and human profilaggrin, as well as to the antigenic proteins of which said antigens are composed and to the peptide fragments derived therefrom. The invention relates to the use of these antigens, proteins and peptide fragments, and that of filaggrin and human profilaggrin, for the preparation of antigenic compositions, and to their applications, in particular for the diagnosis of rheumatoid arthritis. The invention also relates to the preparation of antibodies directed towards these antigens, and to their applications.
REFERENCES:
Huet et al, Ann Rheum Dis SO(9): 611-618, 1991.
Dale et al., "Characterization of Two Monoclonal Antibodies to Human Epidermal Keratohyalin: Reactivity with Filaggrin and Related Proteins", The Journal of Investigative Dermatology, vol. 88, No. 3, Mar. 1987, pp. 306-313.
Lonsdale-Eccles et al., "High-Molecular-Weight Precursor of Epidermal Filaggrin and Hypothesis for its Tandem Repeating Structure", Biochemistry, vol. 23, No. 6, 1984, pp. 1239-1245.
Chemical Abstracts, vol. 103, No. 25, Dec. 23, 1985, p. 605, Abstract No. 211908: Fleckman et al., "Profilaggrin, a high-molecular-weight precursor of filaggrin in human epidermis and cultured keratinocytes" (J. Invest. Dermatol., 1985, 85(6), 507-12).
Hoet et al., "The Perinuclear Factor, a Rheumatoid Arthritis-Specific Autoantigen, is Not Present in Keratohyalin Granules of Cultured Buccal Mucosa Cells", Clinical and Experimental Immunology, vol. 84, No. 1, Apr. 1991, pp. 59-65.
Meek et al., "Epidermal Filaggrin is Synthesized on a Large Messenger Ribonucleic Acid as a High-Molecular-Weight Precursor", Biochemistry, vol. 22, No. 21, Oct. 11, 1983, pp. 4867-4871.
Serre et al., "Anticorps Anti-Stratum Corneum D'Oesophage De Rat, Auto-Anticorps Anti-Keratines Epidermiques Et Anti-Epiderme Dans La Polyarthrite Rhumatoide Et Differentes Affections Rhumatologiques", Revue Du Rhumatisme, vol. 53, No. 11, 1986, pp. 607-614.
Harding et al., "Histidine-rich Proteins (Filaggrins): Structural and Functional Heterogeneity during Epidermal Differentiation", Journal of Molecular Biology, vol. 170, No. 3, Nov. 1983, pp. 651-673.
Serre Guy
Somme Gerard
Vincent Christian
Biomerieux S.A.
Housel James C.
Ryan V.
Seltzer Bell
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