Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Phosphoproteins – e.g. – phosvitin – vitellogenin – etc.
Reexamination Certificate
2007-09-28
2011-12-06
Yu, Misook (Department: 1642)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Phosphoproteins, e.g., phosvitin, vitellogenin, etc.
C530S350000
Reexamination Certificate
active
08071721
ABSTRACT:
The present invention provides novel human protein antigens and related antibodies that have been identified as being specifically expressed in association to human Pancreatic Ductal Adenocarcinoma (PDA). In particular, novel phosphorylated isoforms of alpha-enolase have been identified in transformed cell lines of pancreatic origin and antibodies binding such isoforms are specifically present in the sera of PDA patients. These proteins and antibodies can be useful for the diagnosis and the treatment of PDA and other cancers having common molecular features.
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Cappello Paola
Novelli Francesco
Tomaino Barbara
Bioline Diagnostici SRL
Marshall & Gerstein & Borun LLP
Ribovax Biotechnologies S.A.
Yao Lei
Yu Misook
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