Antigenically active polypeptide and a process for its preparati

Details Antigenically active polypeptide and a process for its preparati Antigenically active polypeptide and a process for its preparati

1977-04-21

1978-08-15

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Reduced antigenicity, reduced ability to bind complement, or...

2601125R, A61K 3700, C07C10352

Patent

active

041072987

ABSTRACT:
The invention provides for a synthetic antigenically active polypeptide containing an immunologically inert portion and as an active immunological determinant group the amino acid sequence A.sub.-3 -A.sub.-2 -A.sub.-1 -A.sub.0 -A.sub.1 -A.sub.2 -A.sub.3, wherein A.sub.0 is an arginine residue, A.sub.1, A.sub.2, A.sub.-1 and A.sub.-2 are the same or different and selected from residues of: glycine, alanine, valine, leucine, lysine, and isoleucine and A.sub.3 and A.sub.-3 are same or different and selected from glutamic acid and aspartic acid. The invention also provides for a process for the preparation of such polypeptide.

REFERENCES:
patent: 3715190 (1973-02-01), Won Kil Park et al.
patent: 3929756 (1975-12-01), Leeman et al.
patent: 3960827 (1976-06-01), Bjorklund
patent: 4018753 (1977-04-01), Inouye et al.

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