Antigenic proteins of Borrelia burgdorferi

Details Antigenic proteins of Borrelia burgdorferi Antigenic proteins of Borrelia burgdorferi

1993-02-19

1995-11-28

Bidwell, Carol E.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435970, 435975, 435 712, 4353201, 530350, 530810, 530825, 536 237, G01N 33569

Patent

active

054707129

ABSTRACT:
The present invention relates to antigenic proteins specific to Borrelia burgdorferi which have a molecular weight of 28 kDa or 39 kDa as determined by SDS-PAGE and are reactivity with Lyme borreliosis serum or fragments thereof and to the corresponding DNA. The proteins, especially the 39 kDa proteins (.alpha. and .beta.) can be used to diagnosis mammals previously or currently infected with the Lyme borreliosis causing agent.

REFERENCES:
patent: 4888276 (1989-12-01), Shelburne
Nadal et al, "Immunoblot Analysis of Antibody Binding to Polypeptides of Borrelia burgdorferi in Children with Different Clinical Manifestations of Lyme Disease", Ped. Res., 26(4):377-382 (1989).
Simpson et al. "Reactivity of Human Lyme Borreliosis sera with a 39-kilodalton Antigen Specific to Borrelia burgdorferi", J. Clin. Microbiol., 28(6):1329-1337 (Jun. 1990).
Wallich et al, Infect. Immun., 58(6):1711-1719 (Jun. 1990).
Magnarelli et al, J. Inf. Dis. 159(1):43-49 (Jan. 1989).
Hansen et al., J. Clin. Microbiol. 26(2):338-346 (Feb. 1988).
Grodzicki et al, J. Inf. Dis. 157(4):790-797 (Apr. 1988).
Cunningham et al, Ann. N.Y. Acad. Sci. 539:376-378 (1988).
Barbour, Clin. Microbiol. Rev. 1(4):399-414 (Oct. 1988).
Benach et al, J. Immunol. 140(1):265-272 (Jan. 1, 1988).

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