Antigenic preparations and the isolation of such preparations

Details Antigenic preparations and the isolation of such preparations Antigenic preparations and the isolation of such preparations

1995-06-07

2000-10-03

Housel, James C.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using a micro-organism to make a protein or polypeptide

435 712, 4351739, 435272, 4242401, 4242541, 4242531, 4242341, 4241841, 530412, 530413, 530825, C12P 2104, C12N 1300, C07K 100, A61K 3910

Patent

active

061271519

ABSTRACT:
A method of deriving an antigen from Bordetella pertussis, wherein the antigen is characterized by the following features: a relative molecular weight of about 67,000 to 73,000 as determined by 12%(w/w) polyacrylamide gel electrophoresis and a proline:glutamic acid ratio of about 1:1 as determined by amino acid analysis. The method comprises: (a) culturing Bordetella pertussiscells; (b) treating the culture of (a) to obtain an outer membrane fraction; and (c) isolating the antigen from the outer membrane fraction of (b).

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