Antigenic polysaccharide specific to Brucella abortus and Yersin

Details Antigenic polysaccharide specific to Brucella abortus and Yersin Antigenic polysaccharide specific to Brucella abortus and Yersin

1985-02-26

1989-05-16

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 11, 536 187, 536 551, 435101, 435822, 424 92, C08B 3700, C07H 504, C12P 1904, A61K 3902

Patent

active

048311260

ABSTRACT:
The antigenic O-chain polysaccharides from Brucella abortus and Yersinia enterocolitica serotype 0:9 have similar structure, i.e. 1-2 linked 4,6-dideoxy-4-formamido-.alpha.-D-mannopyranosyl units. The antigen is more readily isolated from the Yersinia and may be chemically modified to have a hydrophobic moiety attached thereto. The antigen can be adsorbed or coupled to carriers suitable for immunoassay use such as ELISA and RIA. A monoclonal antibody capable of specifically binding to B. abortus and Y. enterocolitica, has been produced. Assay procedures and kits therefor, are described.

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