Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Patent
1992-03-16
1994-09-20
Nucker, Christine M.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
514 8, 514 12, 530324, 530395, 4242661, A61K 3900, C07K 1508, C07K 900
Patent
active
053487400
ABSTRACT:
This invention relates to polypeptide antigens of T.ovis suitable for use in vaccines to protect ruminants against infection by cestode parasites. The antigens are preferably obtained by expression of DNA coding therefor in a recombinant host cell. Aspects of the invention include DNA encoding the antigens, vectors containing the DNA and hosts which express the antigens.
The invention also provides antibody and DNA probes for use in identifying protective antigens of cestode parasites other than T.ovis.
REFERENCES:
patent: 5192638 (1993-03-01), Harrison et al.
Craig, P. S., et al., Dialog file 155, Accession Number 04796656 (abstract only): from Z. Parasitenkd 67(2):197-209 (1982), "Antibody responses of experimentally infected lambs to antigens collected of Taenia hydatigena and Taenia ovis with further observations on anti-oncospheral antibodies".
Howell, M. J., et al., Mol. Biochem. Parasitol. 28:21-30 (Feb. 17, 1988), "Cloning and expression of Taenia ovis antigens in Escherichia coli".
Howell, M. J. et al. Int. J. Parasitol. 19(6):631-638 (1989), "Characterization of cloned antigens of Taenia ovis".
Johnson, K. S., et al., Nature 338: 585-587 (Apr. 13, 1989), "Vaccination against ovine cysticercosis using a defined recombinant antigen".
Osborn, P. J., et al., Res. Vet. Sci. 32: 351-353 (1982), "Vaccination of sheep against Taenia ovis. The response to various dose rates of antigens obtained by incubation of oncospheres in vitro".
Rickard, M. D., et al., Australian Vet. J. 52:209-214 (May, 1976), "Vaccination of lambs against infection with Taenia ovis".
Rickard, M. D., Adv. Parasitol. 21: 229-296 (1982), "Hydatidosis/Cysticercosis immune mechanisms and immunization against infection".
Dempster Robert P.
Harrison Gavin B. L.
Heath David D.
Johnson Kevin S.
Lawrence Stephen B.
Coopers Animal Health NZ Ltd.
Cunningham Thomas
Ministry of Agriculture & Fisheries
Nucker Christine M.
University Of Melbourne
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