Antigenic peptides for growing hepatitis C virus, kit comprising

Details Antigenic peptides for growing hepatitis C virus, kit comprising Antigenic peptides for growing hepatitis C virus, kit comprising

1996-07-24

1998-09-01

Woodward, Michael P.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

530324, 530325, 530326, 4242281, C12Q 170, C07K 1418, A61K 3929

Patent

active

058009825

ABSTRACT:
The present invention relates to an NS4-related antigenic peptide capable of reacting specifically with antibodies directed against Group I of hepatitis C virus (HCV); to an NS4-related antigenic peptide capable of reacting specifically with antibodies directed against Group II of HCV; to a kit for identifying HCV Groups I or II which comprises said peptides in separate sections; and to methods for grouping HCV. The peptides of the present invention can be used to detect HCV Groups I or II specifically as well as the detection of patients having the mixed infection, by which HCV Group II-infected patients can receive early interferon treatment effectively. The peptides are also useful for diagnosis of HCV infection.

REFERENCES:
patent: 5247067 (1993-09-01), Arima et al.
Stuyuer et al., "Analysis of the Putative E1 Envelope and NSAa . . . ," Biochem Biophys Res Comm 192: 635-641 (1993).
Geyson et al., "Cognitive Features of Continuous Antigenic . . . , " J Molec Recog 1: 32-41 (1988).
Houghten et al., "The Use of Synthetic Peptide Combinatorial . . . , " BioTechniques 13: 412-421 (1992).
Sallberg et al., "Immune Response to a Single Peptide . . . , " Immunol Lett 33: 27-34 (1992).
K. Tsukiyama-Kohara et al., Virology, "Antigenicities of Group I and II Hepatitis C Virus Polypeptides--Molecular Basis of Diagnosis", 192, pp. 430-437 (1993).
P. Simmonds et al., Journal of Clinical Microbiology, "Mapping of Serotype-Specific, Immunodominant Epitopes in the NS-4 Region of Hepatitis C Virus (HCV): Use of Type-Specific Peptides to Serologically Differentiate Infections with HCV Types 1, 2 and 3", 31:6, pp. 1493-1503, (Jun. 1993).
Kyoko Tsukiyama-Kohara et al., Virus Genes, "A Second Group of Hepatitis C Viruses", 5:3, pp. 243-254, (1991).
Hiroaki Okamoto et al., Virology, "Full-Length Sequence of a Hepatitis C Virus Genome Having Poor Homology to Reported Isolates: Comparative Study of Four Distinct Geneotypes", 188, pp. 331-341 (1992).

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