Antigenic peptide fragments of VapA protein, and uses thereof

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...

Reexamination Certificate

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C435S069100, C435S069700, C435S252310, C435S252320, C435S320100, C435S471000, C435S473000, C435S173300, C435S252330, C536S023700, C536S024300

Reexamination Certificate

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10258829

ABSTRACT:
An isolated peptide fragment of the VapA protein that binds antibodies specific forRhodococcus equiand the VapA protein. In a preferred form the peptide contains an amino acid sequence of 5 or more amino acid residues that is identical to or homologous to the amino acid sequence of at least one region of the VapA protein that is responsible for immunological recognition. Methods of diagnosing a vertebrate for the presence ofR. equiusing the peptide and methods of vaccinating a vertebrate againstR. equiusing the peptide are also claimed.

REFERENCES:
patent: 2125426 (1995-09-01), None
Burgess et al., The Journal of Cell Biology, 111:2129-2138, 1990.
J Clin Microbiol. Apr. 1996; 34(4):1034-7.
Infect Immun. Nov. 1991;59(11):4056-60.
J Clin Microbiol. Jul. 1997;35(7):1904-8.
Tan, C. et al., “Molecular Characterization of a Lipid-modified Virulence-associated Protein ofRhodococcus equiand its Potential in Protective Immunity”Can J. Vet Res. 1995; 59 pp. 51-59.
Sekizaki, T. et al., “Sequence of theRhodococcus equigene encoding the virulence-associated 15—17-kDa antigens” Gene, 155 (1995); 59 pp. 135-136.

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