Antigenic peptide for detecting anti-hepatitis C virus antibodie

Details Antigenic peptide for detecting anti-hepatitis C virus antibodie Antigenic peptide for detecting anti-hepatitis C virus antibodie

1991-08-13

1994-04-12

Nucker, Christine M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

530326, 436820, C12Q 170, C07K 708

Patent

active

053025075

ABSTRACT:
The antigenic peptide represented by the following amino acid sequence (SEQ ID NO: 1) ##STR1## and a method of the detection of anti-HCV antibodies wherein the above peptide is brought into contact with a sample under the conditions that the peptide is bound to anti-HCV antibodies present in the sample to form an immunological complex and the formation of the immunological complex is measured to confirm the existence of the anti HCV antibodies in the sample. The method is highly specific and sensitive to anti-HCV antibodies.

REFERENCES:
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patent: 5106726 (1992-04-01), Wang
Chiba et al., Proc. Natl. Acad. Sci. 88:4641-45 (1991).
Harada et al., J. Virology 65:3015-3021 (1991).
Kato et al., Jpn J Cancer Res 81:1092-1094 (1990).
Muraiso et al., Biochem Biophys. Res. Comm. 172:511-516 (1990).

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