Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2007-02-20
2007-02-20
Zeman, Robert A. (Department: 1645)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C424S247100
Reexamination Certificate
active
10194489
ABSTRACT:
A vaccine utilizing purified mutant alpha toxins fromClostridium septicumfor humans and animals against infections caused byC septicum. Persons potentially affected byC. septicuminfections include colonic cancer patients, diabetics, leukemia patients, and neutropenics. The alpha toxin mutant of the vaccine lacks the toxicity of a nativeC. septicumalpha toxin. A serum comprising antibodies raised to the alpha toxin mutant is also available for treating humans or animals againstC. septicuminfections. The serum may be used in a method for conferring passive immunity againstC. septicum. Antibodies to the alpha toxin mutant may be used in diagnostic tests or in treatments to clear alpha toxin from bodily fluids. The mutant alpha toxin may be produced by recombinant methods using cDNA encoding the toxin, the cDNA contained for example in a plasmid or host cell.
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Melton Jody
Tweten Rodney K.
Dunlap Codding & Rogers P.C.
Gangle Brian J.
The Board of Regents of the University of Oklahoma
Zeman Robert A.
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