Antigenic modification of polypeptides

Details Antigenic modification of polypeptides Antigenic modification of polypeptides

1985-12-04

1987-12-15

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530326, 530403, A61K 3743, C07K 708, C07K 710

Patent

active

047133660

ABSTRACT:
Endogenous and exogenous proteins, and fragments thereof, are chemically modified outside the body of an animal so that when injected into the animal they produce more antibodies against the unmodified protein than would injection of the unmodified protein or fragment alone. The chemical modification may be accomplished by attaching the proteins or fragments to carriers such as, for example, bacterial toxoids. The chemical modification can also be accomplished by polymerization of protein fragments. Proteins which can be modified include Follicle Stimulating Hormone and Human Chorionic Gonadotropin. The modified polypeptides may be administered to animals for the purpose of contraception, abortion or treatment of hormone-related disease states and disease disorders, treatment of hormone-associated carcinomas, and to boost the animals resistance to exogenous proteins, for example viral proteins.

REFERENCES:
patent: 2301532 (1942-11-01), Fell
patent: 2372066 (1945-03-01), Fell
patent: 2388260 (1945-11-01), Friedhelm
patent: 2744890 (1956-05-01), Wagner
patent: 3317400 (1967-05-01), Reusser
patent: 4122166 (1978-10-01), Tribble et al.
patent: 4123519 (1978-10-01), Tribble et al.
patent: 4161519 (1979-07-01), Tolwar
patent: 4179337 (1979-12-01), Davis et al.
patent: 4193982 (1980-03-01), Avrameas et al.
patent: 4201770 (1980-05-01), Stevens
patent: 4302386 (1981-11-01), Stevens
patent: 4400316 (1983-08-01), Katsuragi et al.
B. Cinader et al., J. of Experimental Medicine, vol. 125, No. 6, pp. 105, 1073 (1967).
W. E. Nixon et al., J. Lab. Clin. Med. (1971), vol. 78, No. 6, pp. 949-956.
S. J. Gross et al., Immunochemistry, vol. 5, pp. 55-65 (1968).
M. Tabachnick et al., J. of Biological Chemistry, vol. 235, 1960, pp. 1051-1054.
Currie, J. Obstet. Gynaec. Brit. Cwlth., vol. 74, pp. 845-848 (1967).
Nisula et al, Cancer Res. vol 34, pp. 512-515 (1974).
W. R. Jones, Immunological Fertility Regulation, Blackwell Scient. Publications, Victoria, Australia (1982), pp. 130-146, 158-171, 207-267.

Affiliated with

Also associated with

Rating

Antigenic modification of polypeptides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antigenic modification of polypeptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antigenic modification of polypeptides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1220277