Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...
Patent
1978-08-25
1980-05-06
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Reduced antigenicity, reduced ability to bind complement, or...
2601125R, 424 88, A61K 3700, C07C10352, A61K 3900
Patent
active
042017700
ABSTRACT:
Modified hormones or fragments of hormones are useful in producing antibodies when administered to an animal. Said antibodies in turn cause neutralization of endogenous natural protein hormones. The modification may be accomplished by attaching various kinds of modifying groups to the hormone or fragment. Modification may, for example, be achieved by chemically coupling diazosulfanilic acid groups to the hormone or fragment. The protein hormones to which this procedure can be applied are mammalian protein reproductive hormones such as, for example, Follicle Stimulating Hormone (FSH), or Human Chorionic Gonadotropin (HGG). These modified hormone or fragment may be administered to animals for the purpose of contraception, abortion, or treatment of hormone related disease states and disorders.
REFERENCES:
Tung, Int. J. Fertil. 21, 197-206, 1976.
Pilsworth, New Scientist, 1978, pp. 665-667.
Laurence, et al., Internat. Journal of Fertility, 1969, 14, 8-15.
Laurence, et al., Endocrinology, 82, 1190-1199, 1968.
Immunochemistry, 1968, 5, 55-65.
Brit. Med., Bull., 26, 72-78, 1970.
Endocrinology 87, 1181-1185, 1970.
Proc. Soc. Expte. Biol. and Med., 133 (1920), 410-415.
Phillips Delbert R.
The Ohio State University
LandOfFree
Antigenic modification of polypeptides does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antigenic modification of polypeptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antigenic modification of polypeptides will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1005048