Antigenic modification of polypeptides

Details Antigenic modification of polypeptides Antigenic modification of polypeptides

1980-01-16

1981-11-24

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260112R, 424177, 424 88, 424 89, C07C10352, C07G 700, A61K 3700, A61K 3900

Patent

active

043023860

ABSTRACT:
Modified hormones or fragments of hormones are useful in producing antibodies when administered to an animal. Said antibodies in turn cause neutralization of endogenous natural protein hormones. The modification may be accomplished by attaching various kinds of modifying groups to the hormone or fragment. Modification may, for example, be achieved by chemically coupling diazosulfanilic acid groups to the hormone or fragment. The protein hormones to which this procedure can be applied are mammalian protein reproductive hormones such as, for example, Follicle Stimulating Hormone (FSH), or Human Chorionic Gonadotropin (HGG). These modified hormone or fragment may be administered to animals for the purpose of contraception, abortion, or treatment of hormone related disease states and disorders.

REFERENCES:
patent: 2301532 (1942-11-01), Fell
patent: 2372066 (1945-03-01), Fell
patent: 2388260 (1945-11-01), Friedhelm
patent: 2744890 (1956-05-01), Wagner
patent: 3317400 (1967-05-01), Reusser
patent: 4122166 (1978-10-01), Tribble et al.
patent: 4123519 (1978-10-01), Tribble et al.
patent: 4161519 (1979-07-01), Tolwar
patent: 4179337 (1979-12-01), Davis, et al.
patent: 4193982 (1980-03-01), Avrameas et al.
patent: 4201770 (1980-05-01), Sterens
B. Cinader et al., J. of Experimental Medicine, vol. 125, No. 6, pp. 1057-1073 (1967).
W. E. Nixon et al., J. Lab. Clin. Med. (1971), vol. 78, No. 6, pp. 949-956.
S. J. Gross et al., Immunochemistry, vol. 5, pp. 55-65 (1968).
M. Tabachnick et al., J. of Biological Chemistry, vol. 235, 1960, pp. 1051-1054.

Affiliated with

Also associated with

Rating

Antigenic modification of polypeptides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antigenic modification of polypeptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antigenic modification of polypeptides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2174287