Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1983-03-04
1985-07-02
Phillips, Delbert R.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
260112R, C07C10352, C07G 700
Patent
active
045267162
ABSTRACT:
Modified hormones or fragments of hormones are useful in producing antibodies when administered to an animal. Said antibodies in turn cause neutralization of endogenous natural protein hormones. Also, non-endogenous proteins or peptides (for example viral proteins or fragments thereof) can be modified to increase an animal's immune response thereto. These modification may be accomplished by attaching various kinds of modifying groups to the hormone or fragment. Modification may, for example, be achieved by chemically coupling diazosulfanilic acid groups to the hormone or fragment. The protein hormones to which this procedure can be applied are mammalian protein reproductive hormones such as, for example, Follicle Stimulating Hormone (FSH), or Human Chorionic Gonadotropin (HCG). These modified polypeptides may be administered to animals for the purpose of contraception, abortion, or treatment of hormone-related disease states and disorders, including hormone-associated carcinomas.
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Millard Sidney W.
Phillips Delbert R.
The Ohio State University
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