Antigenic material

Details Antigenic material Antigenic material

1981-05-18

1982-07-27

Lieberman, Allan

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07G 700

Patent

active

043416977

ABSTRACT:
A novel, glycoprotein antigen obtained from T. cruzi organisms can be used in vaccines for inducing immunity in humans to Chagas' disease. The glycoprotein is extracted by treating trypanosomes with a detergent and separating it from the cell debris and other proteinaceous material by affinity chromatography using lectin with affinity for glucose, mannose or galactose.

REFERENCES:
patent: 3911097 (1975-10-01), Hanson
patent: 4298596 (1981-11-01), Snary
Scott & Snary, Nature, vol. 282, pp. 73-74, Nov. 1979.
Gottlieb, M., Journal of Immunology, vol. 119, No. 2, pp. 465-470, Aug. 1977.
Chem. Abstr., 91: 2327q, Apr. 1979.
Cross, G., Nature, vol. 277, pp. 310-312, Jan. 1979.

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