Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Chemical modification or the reaction product thereof – e.g.,...
Reexamination Certificate
2005-09-13
2005-09-13
Ewoldt, G. R. (Department: 1644)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Chemical modification or the reaction product thereof, e.g.,...
C530S300000, C530S403000, C530S415000, C530S387300
Reexamination Certificate
active
06943239
ABSTRACT:
The present invention relates to an antigenic fusionprotein, which carries multiple Galα1,3Gal epitopes. The fusion protein according to the invention may also be comprised of a heavily glycosylated mucin part, which mediates binding to selectins, such as PSGL-1, and a part, which exhibits immunoglobulin properties, such as the Fc part of IgG. The fusionprotein according to the invention is preferably used as an absorber to prevent a hyperacute rejection of a xenotransplant, such as a pig tissue or organ transplanted into a human patient. In addition, the invention relates to a method for the prevention of hyperacute rejection reaction in a patient who is to receive a xenotransplant.
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R. Rieben et al., “Detection, Immunoabsorption, and Inhibition of Cytotoxic Activity of Anti-alpha-Gal Antibodies Using Newly Developed Substances with Synthetic Gal alpha-1-3Gal Disaccharide Epitopes”, Dialog Information Services, file 5:Biosis Previews (R), Xenotransplantation 2 (2), 1995.
Mauro S. Sandrin et al., “Natural Human Anti-Galα(1,3) Gal Antibodies React with Human Mucin Peptides”, Glycoconjugate Journal (1997) 14:97-105, pp. 97-104.
Holgersson Jan
Liu Jining
Absorber AB
Elrifi Ivor R.
Ewoldt G. R.
Kozakiewicz Cynthia A.
Mintz Levin Cohn Ferris Glovsky and Popeo P.C.
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