Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1989-12-22
1992-02-18
Moskowitz, Margaret
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530388, 435 7021, 4351722, 43524027, 935106, 935 95, C07K 1528, C12N 500
Patent
active
050896032
ABSTRACT:
Antigenic epitopes associated with the extracellular segment of the domain which anchors immunoglobulins to the B cell membrane are disclosed. For IgA, the epitopes are present on IgA-bearing B cells but not the secreted, soluble form of IgA. The epitopes can be exploited for therapy and prophylaxis. For example, antibodies specific for the epitopes associated with the anchor and peptide encompassing the epitope domain of IgA can be used to increase secretory IgA production for the purposes of treating patients with infectious diseases and IgE-mediated allergic diseases.
REFERENCES:
Cushley et al., Nature, vol. 298, 1982, pp. 577-579.
Whittler et al., Protein Engineering vol. 6, pp. 499-505.
Burnett, R. C. et al., "The IgA Heavy Chain Gene Family in Rabbit:Cloning & Sequence Analysis of 13 C-62 Genes", Embo Journal 8: 4041-47 (1989).
Robinson, E. A. et al., "Complete Amino Acid Sequence of a Mouse Immunoglobulin .beta.Chain (MOPC 511)", PNAS 11:4909-13 (1980).
Osborne, B. A. et al., "Evolution of the Genes", Dialog Database R65 Genetics 119:925-32 (1988).
Loghem, E. V. et al., "Allotypic and Isotypic Aspects of Human Immunoglobulin A", Molecular Immunology, vol. 20 (1983).
Word et al., "The Murine Immunoglobulin .beta.Gene Expresses Multiple Transcripts from a Unique Membrane Exam", (particularly; p. 895, 2nd col.), Embo Journal 2:887-898 (1983).
Blattner et al., Nature, vol. 307, 2 Feb. 1984, pp. 417-422.
Chang Nancy T.
Chang Tse-wen
Budens Robert D.
DeConti, Jr. Giulio A.
Mirabel Eric P.
Moskowitz Margaret
Tanox Biosystems, Inc.
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