Antigenic epitopes present on membrane-bound but not secreted Ig

Details Antigenic epitopes present on membrane-bound but not secreted Ig Antigenic epitopes present on membrane-bound but not secreted Ig

1990-01-23

1993-11-09

Lee, Lester L.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

11 to 14 amino acid residues in defined sequence

5303872, 5303873, 53038873, 530862, 530868, 424 858, C07K 708, C07K 1702

Patent

active

052604160

ABSTRACT:
Antigenic epitopes associated with the extracellular segment of the domain which anchors immunoglobulins to the B cell membrane are disclosed. For IgE, the epitopes are present on IgE-bearing B cells but not basophils or the secreted, soluble form of IgE. The epitope can be exploited for therapy and diagnosis. For example, antibodies or immunotoxins specific for the epitopes associated with the anchor domain of IgE can be used to selectively destroy IgE-bearing lymphocytes, thus blocking IgE-mediated allergic reactions.

REFERENCES:
Ishida, et al., The EMBO Journal, 1(9): 1117-1123, 1982.
Cheng, et al., Nature, 296: 410-415, 1982.
Word et al. "The Murine Immunoglobulin .alpha. Gene Expresses Multiple Transcripts from a Unique Membrane Exon" (particularly; p. 895, 2nd column) EMBO Journal 2: 887-898 (1983).
Blattner, F. R. & Tucker, P. W. Nature 307: 417-422 (1984) (p. 418 col. 1).
Steen, M. L. et al. J. Mol. Biol. 177: 19-32 (1984).
Rogers, J. et al. Cell 26: 19-27 (1981).
Komaromy, M. et al. Nuc. Acids Res. 11: 6775-85 (1983).
Rogers, J. et al. Cell 20: 303-12 (1980).
Bernstein, K. E., J. Immunol. 132: 490-95 (1984).
Tyler et al. PNAS USA 74: 2008-12 (1982).

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