Antigenic epitopes and mosaic polypeptides of hepatitis C...

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector

Reexamination Certificate

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C424S185100, C424S186100, C424S189100, C424S199100, C424S196110, C424S228100, C424S009100, C435S005000, C435S007100, C530S350000, C530S300000

Reexamination Certificate

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07052696

ABSTRACT:
Antigenic epitopes of hepatitis C virus (HCV) and mosaic HCV polypeptides useful as reagents in assays for the diagnosis or monitoring of HCV in a biological sample. The antigenic epitopes and mosaic polypeptides are also useful for the construction of immunogenic pharmaceutical compositions, such as vaccines. The mosaic polypeptides are artificial composite proteins constructed from diagnostically relevant antigenic regions derived from different HCV proteins. Preferably, the mosaic polypeptides contain antigenic epitopes from the core protein, NS3 protein, and NS4 protein. The preferred mosaic polypeptides optionally contain an additional antigenic epitope from either the NS4 protein or the NS5a protein or both.

REFERENCES:
patent: 4683202 (1987-07-01), Mullis
patent: 4722848 (1988-02-01), Paoletti et al.
patent: 4946778 (1990-08-01), Ladner et al.
patent: 5426039 (1995-06-01), Wallace et al.
patent: 5683864 (1997-11-01), Houghton et al.
patent: 6150087 (2000-11-01), Chien
patent: 6428792 (2002-08-01), Valenzuela et al.
patent: 0464 287 (1992-08-01), None
patent: 0805 160 (1997-11-01), None
patent: 07322881 (1994-05-01), None
patent: WO 97/44469 (1997-11-01), None
Chien et al. (a) P.N.A.S. USA. 1992, vol. 89, pp. 10011-10015.
Chien et al. (b) J. Gastro. Hepto. 1993, vol. 8, pp. S33-S39.
Kato et al. P.N.A.S. USA. 1990, vol. 87, pp. 9524-9528.
Jin et al. Arch. Biochem. Biophy. 1995, vol. 323, No. 1, pp. 47-53.
Barrera et al. Vox Sang 1995, vol. 68, pp. 15-18.
Hijitkata et al. Proc. Natl. Acad. Sci. USA, 1993, vol. 90, pp. 10773-10777.
Eisenbraun et al., Examination of Parameters Affecting the Elicitation of Humoral Immune Responses by Particle Bombardment-Mediated Genetic Immunization.DNA Cell Biol. 12(9):791-797 (1993).
Miller et al., Vaccination of Rhesus Monkeys with Synthetic Peptide in a Fusogenic Proteoliposome Elicits Simian Immunodeficiency Virus-Specific CD8+ Cytotoxic T lymphocytes.J. Exp. Med.176:1739-1744 (Dec. 1992).
Wolff et al., Long-term persistence of plasmid DNA and foreign gene expression in mouse muscle.Hum. Mol. Genet.1(6):363-369 (1992).
Chien et al., Diagnosis of Hepatitis C Virus (HCV) Infection using an Immunodominant Chimeric Polyprotein to Capture Circulating Antibodies: Reevaluation of the Role of HCV in Liver Disease.Proc Natl. Acad. Sci. USA89:10011-10015 (Nov. 1992).
Tang et al., Genetic immunization is a simple method for eliciting an immune response.Nature356:152-154 (Mar. 12, 1992).
Goodman-Snitkoff et al., Role of intrastructural/intermolecular help in immunization with peptide-phospholipid complexes.J. Immunol. 147(2):410-415 (Jul. 15, 1991).
Huse et al., Generation of a Large Combinatorial Library of the Immunoglobulin Repertoire in Phage Lambda.Science246:1275-1281 (Dec. 8, 1989).
Wu et al., Targeting Genes: Delivery and Persistent Expression of a Foreign Gene Driven by Mammalian Regulatory Elementsin Vivo. J. Biol. Chem.264(29):16985-16987 (Oct. 15, 1989).
Ward et al., Binding activities of a repertoire of single immunoglobulin variable domains secreted fromEscherichia coli. Nature341:544-546 (Oct. 12, 1989).
Kaneda et al., Increased Expression of DNA Cointroduced with Nuclear Protein in Adult Rat Liver.Science243:375 (Jan. 20, 1989).
Benvenisty et al. Direct introduction of genes into rats and expression of the genes.Proc. Natl. Acad. Sci. USA83:9551-9555 (Dec. 1986).
Seeger et al., The cloned genome of ground squirrel hepatitis virus is infectious in the animal.Proc Natl. Acad. Sci. USA81:5849-5852 (Sep. 1984).
Kearney et al., A new mouse myeloma cell line that has lost immunoglobulin expression but permits the construction of antibody-secreting hybrid cell lines.J. Immunol.123(4):1548-1550 (Oct. 1979).
Kohler et al., Continuous cultures of fused cells secreting antibody of predefined specificity.Nature256:495-497 (Aug. 7, 1975).
Cuatrecasas. Protein Purification by Affinity Chromatography. Derivatizations of agarose and polyacrylamide beads.J. Biol. Chem.245:3059-3065 (Jun. 25, 1970).
Farci, et al., “The Outcome of Acute Hepatitis C Predicted by the Evolution of the Viral Quasispecies,”Science288(5464):339-344 (Apr. 14, 2000).
Kumar, et al., “Hepatitis B virus envelope epitopes: gene assembly and expression inEscherichia coliof an immuno-logically reactive novel multiple-epitope polypeptide 1 (MEP-1),”Gene110:137-144 (1992).
Presentation entitled, “Epidemiology and Prevention of Viral Hepatitis A to E: An Overview,” Hepatitis Branch, Centers for Disease Control and Prevention, printed from http://www.cdc.gov
cidod/diseases/hepatitis/slideset/intro/hep—intro.pdf (1 page).
Presentation entitled, “Hepatitis B Virus,” Centers for Disease Control and Prevention, printed from http://www.cdc.gov
cidod/diseases/hepatitis/slideset/hep—b/hep—b.pdf (3 pages).
Presentation entitled, “Hepatitis C,” Hepatitis Branch, Centers for Disease Control and Prevention, printed from http://www.cdc.gov
cidod/diseases/hepatitis/slideset/hep—c/hep—c/hcv—epi—for—distrib—000925.pdf, (dated Sep. 25, 2000), (7 pages).
Presentation entitled, “Hepatitis E Virus,” Centers for Disease Control and Prevention, printed from http://www.cdc.gov
cidod/diseases/hepatitis/slideset/hep—e/hep—e.pdf (1 page).
Website: “30.0.1.0.001 Hepatitis B virus,” printed from http://www.ncbi.nlm.nih.gov/ICTVdb/Ictv/index.htm (2 pages).
Website: “ICTVdB Index of Viruses,” printed from http://www.ncbi.nlm.nih.gov/ICTVdb/Ictv/index.htm (5 pages).
Website: “ICTVdB Virus Descriptions,” printed from http://www.ncbi.nlm.nih.gov/ICTVdb/Ictv/index.htm (12 pages).
Yagi et al., “An Epitope Chimeric Antigen for the Hepatitis C Virus Serological Screening Test,”Biol Pharm Bull19(10):1254-1260 (1996).

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