Antigenic conjugates of polycyclic aromatic hydrocarbons to nucl

Details Antigenic conjugates of polycyclic aromatic hydrocarbons to nucl Antigenic conjugates of polycyclic aromatic hydrocarbons to nucl

1996-04-23

1998-12-15

Kunz, Gary L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 221, C07H 100, C07H 19073, C07H 19173

Patent

active

058499067

ABSTRACT:
The present invention relates to novel immunologic reagents and their use in assays for the detection of polycyclic aromatic hydrocarbon (PAH)-DNA or heteropolycyclic aromatic hydrocarbon (HAH)-DNA adducts. These adducts are uniquely important biomarkers for cancer risk due to exposure to environmental PAH and HAH pollutants. More particularly, this invention relates to new hapten-protein conjugates and their use as antigens in the production of antibodies for use in immunological assays for PAH and HAH biomarkers. The invention also relates to novel, chemically-pure DNA adducts of PAH or HAH which form the haptenic moieties of the conjugates of this invention, and to improved methods for their synthesis and isolation.

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G. Kohler et al., (1975) Nature 256: 495-497.
C. Reading (1983) J. Immunol. Meth. 53: 261-291.
Wilk and Girke, Journal of the National Cancer Institute, 49: 1585-1597 (1972).

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