Antigenic composition obtained by V8 proteolysis of a protein fr

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...

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4241841, 4242651, 530350, 5303881, 5303882, 5303886, 435 693, 435 681, A61K 3902, A61K 39002, C07K 1600, C12P 2108

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active

057532362

ABSTRACT:
An antigenic composition against S. mansoni comprising an 8 kD peptidic fragment associated with a suitable vehicle, the 8 kD peptidic fragment being obtained by controlled proteolysis using V8 protease of a 28 kD protein obtained from S. mansoni is described.

REFERENCES:
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Cleveland et al, J. Biol. Chem. 252(3):1102-06, 1977.
Vignali et al, Immunol Today 1012):410-416, 1989.
Shes et al, Parasitology 98 Suppl.:S61-S68, 1989.
Scott et al, Immunol Rev. 112:161-182. 1989.
Huqeunel et al, FASEBJ. 44(3):654 Abstract M26, 1985.
Harn et al. 1985. Mol. Biochem. Parasitology. 16:345-54.
Aron 1991. Vaccine. 9:379-94.

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