Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Reexamination Certificate
2003-09-19
2009-06-02
Navarro, Mark (Department: 1645)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
C424S152100, C424S172100
Reexamination Certificate
active
07541032
ABSTRACT:
Dendritic cells (DC) that express the type II C-type lectin DC-SIGN (CD209) are located in the submucosa of tissues, where they mediate HIV-1 entry. Interestingly, the pathogenCandidaalbicans, the major cause of hospital-acquired fungal infections, is found at similar sites. Here it is demonstrated that DC-SIGN is able to bindCandida albicansboth in DC-SIGN transfected cell lines and in human monocyte derived DC. Moreover, in immature DC, DC-SIGN is able to internalizeCandidain specific DC-SIGN enriched vesicles, distinct from those containing the mannose receptor (MR; CD206), which is anotherCandidareceptor on DC. Together, these results demonstrate thatC. albicanshas two major receptors on human monocyte derived DC, these receptors being DC-SIGN and MR. Targeting of DC-SIGN offers novel opportunities to combat chronic forms of candidiasis.
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Figdor Carl Gustav
Torensma Ruurd
Gangle Brian J
Navarro Mark
Ropes & Gray LLP
Stichting Katholieke Universiteit
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