Antigen specific plasmacytomas and antibodies derived therefrom

Details Antigen specific plasmacytomas and antibodies derived therefrom Antigen specific plasmacytomas and antibodies derived therefrom

1991-09-19

1993-09-14

Weimar, Elizabeth C.

Drug, bio-affecting and body treating compositions

Lymphokine

4352402, 4351723, 424 89, 5303871, 935 57, C12N 500, C12N 1500, A61K 3900

Patent

active

052446565

ABSTRACT:
Disclosed herein is a method for producing antibodies against an antigen of interest. Animal cells are exposed to both the antigen of interest and a recombinant retroviral vector. The vector contains a combination of oncogenes capable of inducing plasmacytomas. Plasmacytoma formation takes place rapidly and takes place in the presence of the antigen. A very high proportion of the plasmacytomas that are recovered are antigen specific.

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