Antigen-specific, activated T lymphocytes, detection and use

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Chemical modification or the reaction product thereof – e.g.,...

Reexamination Certificate

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C530S325000, C530S326000, C530S327000, C530S328000, C530S403000

Reexamination Certificate

active

07064190

ABSTRACT:
The invention concerns autoreactive peptides, peptide-MHC complexes, T cell subpopulations that react thereto as well as diagnostic and therapeutic applications of these compounds.

REFERENCES:
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“Glutamic Acid Decarboxylase 67-reactive T Cells: A Marker of Insulin dependent Diabetes”; Margo C. Honeyman et al., J. Exp. Med. vol. 177 Feb. 1993; pp. 535-540.
“Glutamic Acid Decarboxylase Autoantibodies in Preclinical Insulin dependent Diabetes”; Henry J. De Aizpurua, et al., Proc. Natl. Acad. Sci. USA; vol. 89; Oct. 1992; Medical Sciences; pp. 9841-9845.
“Two Human Glutamate Decarboxylases, 65-kDa GAD and 67-kDa GAD, Are each Encoded By A Single Gene”; Ding-Fang Bu et al.; Proc. Natl.. Acad. Sci. USA; vol. 89; Mar. 1992; Medical Sciences; pp. 2115-2119.
Engelhard, V.H., Curr. Opin. Immunol. 6:13-23, 1994. Structure of peptides associated with MHC Class 1 molecules.
Mauch, L. et al., Eur. J. Biochem. 212:597-603, 1993. Characterization of a linear epitope within the human pnacreatice 64-kDa glutamic acid decarboxylase and its autoimmune recognition by sera from insulin-dependent diabetes melitus patients.
Smilek, D. et al., P.N.A.S. 88:9633-9637, 1991. A single amino acid change in a myelin basis protein peptide confers the capacity to prevent rather than induce experimental autoimmune encephalomyelitis.

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