Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Patent
1994-03-18
1997-02-18
Walsh, Stephen G.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
424 157, 4241931, 530350, 435 693, A61K 3900, A61K 39385, C07K 14705
Patent
active
056039344
ABSTRACT:
An isolated nucleic acid sequence encoding Hu paraneoplastic antigenic polypeptide is provided by this invention. This invention also provides a purified Hu antigenic polypeptide and compositions containing the purified Hu antigenic polypeptide. Further provided by this invention is a monoclonal antibody directed to an epitope on the Hu paraneoplastic antigenic polypeptide. Compositions containing this monoclonal antibody also are provided by this invention. This invention also provides methods of diagnosis and treatment using the compositions described hereinabove.
REFERENCES:
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Graus, F. et al., Acta Neurol. Scand., 75(4): 249-52, 1987.
Dalmau, J. et al., Ann. Neurol., 27(5): 544-552, 1990, May.
Scopes, R., Protein Purification, pp. 111-124 and 132-135, Springer-Verlag, NY, 1982.
Posner, J. et al., "Immunologic Mechanisms in Neurologic and Psychiatric Disease" in Research Publications Assocation for Research in Nervous and Mental Disease, 68:187-220, Raven Press, NY, 1990.
Posner, J. B. et al., Neurology, 40 (4 Suppl. 1): 165, Abstract 178S, Apr. 1990.
Sambrook, J. et al., Molecular Cloning: a Laboratory Manual, Cold Spring Harbor Laboratory Press, NY, 1989, pp. 18.60-18.61.
Szabo, A. et al., Cell, 67:325-333, 1991.
Furneaux Henry M.
Posner Jerome B.
Sloan-Kettering Institute for Cancer Research
Walsh Stephen G.
White John P.
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