Antigen of Blastomyces dermatitidis and its uses

Details Antigen of Blastomyces dermatitidis and its uses Antigen of Blastomyces dermatitidis and its uses

1989-09-14

1992-03-03

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Lymphokine

530371, 530806, 530824, 435 724, 436544, G01N 33532, C07K 1510

Patent

active

050931180

ABSTRACT:
A cell wall protein of the fungus B. dermatitidis is isolated and purified. The protein is readily recognized by serum antibodies from animals having blastomycosis. The protein antigen can be labelled to provide an assay for detection of the disease, it can be used to stimulate specific lymphocyte response and thereby provide another assay for detection of the disease, it can be used to produce an immune response to B. dermatitidis, or it can be used to create antibodies to the protein.

REFERENCES:
patent: 3887431 (1975-06-01), Robbins et al.
patent: 4080260 (1978-03-01), Chao
patent: 4123427 (1978-10-01), Daniel
Green et al, "Preparation of Reference Antisera for Laboratory Diagnosis of Blastomycosis", J. Clin. Microbiol., vol. 10, No. 1, Jul. 1979, pp. 1-7.
Klein et al, "Isolation, Purification, and Radiolabelling of a Novel 120-KD Surface Protein . . . ", J. Clin. Invest., vol. 85, Jan. 1990, pp. 152-161.
Moyers, "The Isolation and Characterization of Soluble Yeast Phase Antigens of Blastomyces Dermatitidis", Diss. Abstr. Int. B. 1979, 40(3), 1066.
L. Kaufman et al., 26 Appl. Microbiol., 244-247 (1973).
R. Cox et al., 10 Infec. Immun. 42-47 (1974).
R. Cox et al., 10 Infec. Immun., 48-53 (1974).
M. Lancaster, 13 Infec. Immun., 758-762 (1976).
F. Deighton et al., 15 Infec. Immun., 429-435 (1977).
J. Green et al., 4 Curr. Microbiol., 293-296 (1980).
K. Young et al., 33 Infec. Immun., 171-177 (1981).
R. Bradsher et al., 33 Infec. Immun., 485-490 (1981).
R. Bradsher, 129 Am. Rev. Respir. Dis., 430-434 (1984).
S. Turner et al., 23 J. Clin. Microbiol., 294-297 (1986).
J. Jones, 30 Infec. Immun., 78-89 (1980).
R. Greenfield, 101 J. Lab. Clin. Med., 758-771 (1983).
B. Klein et al., 314 N. Engl. J. Med., 529-534 (1986).
B. Klein et al., 133 Am. Rev. Respir. Dis., 144-148 (1986).
B. Klein et al., 155 J. Infec. Dis., 262-268 (1987).
B. Klein et al., 136 Am. Rev. Respir. Dis., 1333-1338 (1987).
F. Kanetsuna et al., 97 J. Bacteriol., 1036-1041 (1969).
F. Kanetsuna et al., 106 J. Bacteriol., 946-948 (1971).
K. Lee et al., 13 Sabouraudia, 148-153 (1975).
E. Reiss, Molecular Immunology of Mycotic and Actinomycotic Infections, 77-102, Elsevier/N.Y. (1986).
U. Laemmli, 227 Nature, 680-685 (1970).
J. Heukeshoven et al., 6 Electrophoresis, 103-112 (1985).
R. Kapitany et al., 56 Anal. Biochem., 361-369 (1973).
H. Towbin et al., 76 P.N.A.S., USA, 4350-4354 (1979).
P. Minden et al., Handbook of Experimental Immunology, F. A. Davis Co., 463-492 (1967).

Affiliated with

Also associated with

Rating

Antigen of Blastomyces dermatitidis and its uses does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antigen of Blastomyces dermatitidis and its uses, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antigen of Blastomyces dermatitidis and its uses will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-270927