Antigen non-specific glycosylation inhibiting factor derivatives

Details Antigen non-specific glycosylation inhibiting factor derivatives Antigen non-specific glycosylation inhibiting factor derivatives

1996-03-04

1999-06-08

Kemmerer, Elizabeth

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 695, 4352523, 4353201, 530350, 530408, 530402, 536 235, 424 851, C12P 2100, C07K 1446, A61K 3818

Patent

active

059104279

ABSTRACT:
Antigen non-specific human glycosylation inhibiting factor derivatives having the inmunosuppressive activity in which a mutation was introduced for replacement, deletion and/or insertion of a part of the amino acid sequence of SEQ ID NO:21, and/or which has received a chemical modification of one or more amino acid residue(s) in the amino acid sequence of SEQ ID NO:21, wherein the mutation and the chemical modification attenuate the strength of an intermolecular association in the region, which participates in trimerization, of an antigen non-specific human glycosylation inhibiting factor having the amino acid sequence of SEQ ID NO:21; DNAs containing a base sequence encoding the amino acid sequence of the antigen non-specific human glycosylation inhibiting factor derivative; recombinant vectors containing the DNAs; prokaryotic or eukaryotic cells transformed with the DNAs; methods of producing the antigen non-specific human glycosylation inhibiting factor derivatives; pharmaceutical compositions comprising the antigen non-specific human glycosylation inhibiting factor derivative and a pharmaceutically acceptable carrier; and methods of suppressing a human immune response to an antigen are provided.

REFERENCES:
Mikayama, et al., Molecular cloning and functional expression of a cDNA encoding glycosylation-inhibiting factor, Proc. Natl. Acad. Sci. USA, 90:10056, Nov. 1993.
Liu, et al., Requirement of posttranslational modifications for the generation of biologic activity of glycosylation-inhibiting factor, Proc. Natl. Acad. Sci. USA, 91:11227, Nov. 1994.
Suzuki, et al., Crystallization and a Preliminary X-ray Diffraction Study of Macrophage Migration Inhibitory Factor from Human Lymphocytes, J. Mol. Biol., 235:1141, 1994.
Alberts et al., Molecular Biology of the Cell, 1994, Garland Publishing, Inc., New York, NY, p. G16.
Sherman et al. Methionine or not methionine at the beginning of a protein. Bioessays, (Jul. 1985) 3 (1) 27-31.

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