Antigen fragments for the diagnosis of Toxoplasma gondii

Details Antigen fragments for the diagnosis of Toxoplasma gondii Antigen fragments for the diagnosis of Toxoplasma gondii

2007-02-13

2007-02-13

Zeman, Robert A. (Department: 1645)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C530S300000, C530S387100, C435S273000, C435S069300, C435S235100, C435S320100, C424S184100

Reexamination Certificate

active

10508622

ABSTRACT:
The invention described herein relates to a method for identifying antigen fragments ofToxoplasma gondiiproteins, and their use as diagnostic and immunogenic agents. Said method is implemented by means of selection of DNA fragments libraries of the parasite with sera of subjects who have been infected, using the phage display technique, and is characterised in that it uses the expression/exposure vector λKM4. The method allows also to identify antigen fragments related to the time of the infection.

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Beghetto et al (Identification of a human immunodominant B-cell epitope within the GRA1 antigen ofToxoplasma gondiiby phage display of cDNA libraries, International Journal for Parasitology, 2001; 31: 1659-1668).
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Beghetto et al; “Molecular Dissection of the Human B-Cell Response AgainstToxoplasma gondiiInfection by Lambda Display of cDNA libraries”; International Journal for Parasitology, vol. 33, No. 2, Feb. 20, 2003, pp. 163-173, XP001153939.
Beghetto et al; “Identification of a Human Immunodominant B-Cell Epitope Within the Grai Antigen ofToxoplasma gondiiby Phage Display of cDNA Libraries”; International Journal for Parasitology, vol. 31, 2001, pp. 1659-1668, XP001063313.

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